Crystal structure of human ADAMTS-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide)

Protein Data Bank Japan2024-10-09 更新2026-03-21 收录

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Crystal structure of human ADAMTS-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide) Descriptor: 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl}acetamide, A disintegrin and metalloproteinase with thrombospondin motifs 4, CALCIUM ION, ... Authors: Durbin, J.D, Stout, S.L. Deposit date: 2014-10-01 Release date: 2014-12-10 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.24 Å) Cite: Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis. J.Med.Chem., 57, 2014

人源ADAMTS-4（A disintegrin and metalloproteinase with thrombospondin motifs 4）与抑制剂（化合物1：2-(4-氯苯氧基)-N-{[(4R)-4-甲基-2,5-二氧代咪唑烷-4-基]甲基}乙酰胺）结合的晶体结构。数据集描述项：2-(4-氯苯氧基)-N-{[(4R)-4-甲基-2,5-二氧代咪唑烷-4-基]甲基}乙酰胺、含血小板反应蛋白基序的解整合素金属蛋白酶4、钙离子…… 作者：Durbin J.D.、Stout S.L. 保藏日期：2014-10-01 发布日期：2014-12-10 最后修改日期：2024-10-09 实验方法：X射线衍射（分辨率1.24 Å）引用文献：《蛋白聚糖酶-1与蛋白聚糖酶-2的强效选择性乙内酰脲类抑制剂的发现：在骨关节炎化学与手术模型中均显示疗效》，《药物化学杂志》，57卷，2014年

创建时间：

2014-10-01