Species directed therapy for leishmaniasis from the “Old World.”

aAbbreviations used: Cat.: category, TC: treatment of choice, AT: alternative treatment, CI: confidence interval, N/A: not available, VL, CL and MCL: visceral, cutaneous and mucocutaneous leishmaniasis.bPooled efficacy is calculated from studies that may include Fungizone, Ambisome, Abelcet, Amphocil.cData between square brackets refer to studies describing number of healed lesions rather than number of healed patients.dA wait-and-see policy may be considered.eDiffuse cutaneous leishmaniasis requires systemic therapy.fEfficacy data are obtained from a population with low HIV endemicity.gEfficacy data are obtained from a population with high HIV endemicity.hEfficacy data are obtained from immunocompetent patients only; HIV-positive patients were excluded from analysis.