TF-Marker: A comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human.

Here, we developed the TF-Marker database (TF-Marker, http://bio.liclab.net/TF-Marker/) which is committed to a comprehensive manual curation of TFs and related markers with experimental evidence in specific cell and tissue types in human. Currently, through reviewing <strong>2,091</strong> published literature, we have manually classified TFs and related markers into five types according to their functions: 1) <strong>TF</strong>: TFs, which regulate the expression of markers; 2) <strong>T Marker</strong>: markers, which are regulated by TFs (TF and T Marker pairs can identify cell types more specifically); 3) <strong>I Marker</strong>: markers, which influence the activity of TFs (I Markers can also influence the development of specific cells and tissues); 4) <strong>TFMarker</strong>: TFs, which play roles as markers (TFMarkers are cell/tissue-specific TFs used as cell markers in biology experiments); and 5) <strong>TF Pmarker</strong>: TFs, which play roles as potential markers. By curating thousands of published literature, <strong>5,905</strong> entries including <strong>1,316</strong> TFs, <strong>1,092</strong> T Markers, <strong>473</strong> I Markers, <strong>1,600</strong> TFMarkers and <strong>1,424</strong> TF Pmarkers, were annotated in <strong>383</strong> cell types and <strong>95</strong> tissue types in human. Moreover, TF-Marker divided markers into disease markers and tissue/cell-specific markers. TF-Marker is an elaborate database, which provides TFs and related markers supported by experimental evidence. We believe TF-Marker will provide strong support for research into cell/tissue-specific TFs and related markers.