Kinetic Resolution in a Bridgehead Lithiation Mediated by a Chiral Bis-lithium Amide: Assignment of the Absolute Configuration of Clusianone

A chiral base kinetic resolution of an advanced bicyclic
intermediate enabled access to the polyprenylated phloroglucinol natural product (+)-clusianone in enantiomerically
pure form. X-ray structure determination of another product
obtained by the same method then allowed the absolute
stereochemistry of (+)-clusianone to be assigned.