Supplemental Tables S1 – S7

Table S1. Overview of subject characteristics; Table S2. Protein-protein interactions based on mutual information (MI); Table S3. Annotation of 15 proteins of interest with Low (0), Medim (1) or High (2) expression in 2 severity clusters; Table S4(a). Gene Ontology (GO) annotation in Biological Process classes – over-representation analysis of 15 proteins of interest; Table S4(b). Gene Ontology (GO) annotation in Reactome Pathway classes – over-representation analysis of 15 proteins of interest; Table S5. Assignment of subjects into two severity clusters (high frequency = 0; low frequency = 1) based on expression of 15 proteins of interest with Low (0), Medim (1) or High (2) expression; Table S6. Predicted mode of action (polarity) in 100 competing models of a 15 protein co-regulatory network in serum of COPD subjects representative of two exacerbation frequency clusters (activation = +1, absent = 0, inactivation = −1); Table S7. Node metrics for the representative regulatory network of Fig 7. (XLSX)