Analysis of Entropy of sequences and epitope-specific functional responses based on the order of time of appearance of epitope mutations within each individual.

a.The position refers to the position in the HXB2 sequence.b.Optimal defined or predicted epitopic sequences are reported in bold.c. "Undetermined": no epitopes recognized within restricting alleles expressed by the patients have been previously reported.d. Indicates time of the earliest frequency of response detected by ICS assay.e. Virus load (VL) detected at the correspondent week of T cell response (d) is reported in copies/ml.f. The letters indicate the ranking based on appearance of escape mutations or lack thereof. The same letter are used in Figure 5 to indicate the correspondent epitope.g. Epitopes dysplaying mutations related to T cell responses and evidence for variation escape within 55 and 87 WFOSx are listed as early (e-ME) or late (l-ME), respectively; those without evidence for variation and escape are reported as nME. Escape mutant epitopes are listed in order of appearance within each subject.h. The numbers reflect the Shannon entropy as indicated in the Methods section. The higher is the value, the higher is the likelihood for the region to allow for variability in the sequence.i. Each column reports the frequency (Freq) of the population of interest as % of total memory CD8+ T cells.