five

Development of gene expression signatures for CXXC5 in pDCs

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE79643
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We have employed whole genome microarray expression profiling as a discovery platform to identify genes regulated by CXXC5 in pDCs. pDCs (CD11c+B220+CD11b-) were differentitated from wild-type and CXXC5-deficient bone marrows by FLT3L for 6 days and sorted by FACS. Expression of five genes (Irf7,Ccl1,Smtn,Dppa2,Ifnab) from this signature was quantified in the same RNA samples by real-time PCR. Gene expression was measured in WT and CXXC5-deficient pDCs.
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2019-07-08
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