Transcriptional heterogeneity among xenograft tumors derived from subclonal populations of MDA-MBA-468 triple-negative breast cancer cells

Intratumoral heterogeneity has been described for various tumor types and models of human cancer, and can have profound effects on tumor progression and drug resistance. This study describes transcriptional heterogeneity among subclonal populations (SCPs) derived from a single triple-negative breast cancer cell line. Overall design: Bulk RNA-sequencing (RNA-seq) analysis was performed on 4 SCPs of the MDA-MB-468 cell line. Three tumors per SCP were analyzed.