Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs [CITE-Seq]
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE254822
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Through a multi-omics approach, we discovered that metformin acts by enhancing the methylation potential in Dnmt3aR878H/+ cells and reversing their aberrant DNA CpG methylation and histone H3K27 trimethylation (H3K27me3) profiles. To investigate the mechanism of action and explore the expansion of clusters, we performed single-cell RNA Seq profiling of Dnmt3a+/+ and mutant Dnmt3aR878H/+ HSPCs treated with or without metformin for 7 months.
创建时间：
2025-05-09
