Mutational signatures reveal the role of RAD52 in p53-independent p21 driven genomic instability
收藏NIAID Data Ecosystem2026-03-10 收录
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Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential to design appropriate therapeutic strategies. In a recent study we reported an unexpected oncogenic property of p21WAF1/Cip1 showing that its chronic expression, in a p53-deficient environment, causes genomic instability by deregulating the replication licensing machinery.
创建时间：
2018-01-21
