Crystal structure of human monoacylglycerol lipase in complex with compound 1
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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Crystal structure of human monoacylglycerol lipase in complex with compound 1 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 6-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidine-1-carbonyl}-2H-1,4-benzoxazin-3(4H)-one, ACETATE ION, ... Authors: Qin, L, Gay, S.C, Lane, W, Skene, R.J. Deposit date: 2020-12-21 Release date: 2021-08-11 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2 H -benzo[ b ][1,4]oxazin-6-yl Moiety. J.Med.Chem., 64, 2021
人单酰甘油脂肪酶（monoacylglycerol lipase）与化合物1结合的晶体结构 描述符：(4S)-2-甲基-2,4-戊二醇、6-{4-[(2-氯-4-氟苯氧基)甲基]哌啶-1-羰基}-2H-1,4-苯并恶嗪-3(4H)-酮、乙酸根离子等 作者：Qin, L、Gay, S.C、Lane, W、Skene, R.J 提交日期：2020-12-21 发布日期：2021-08-11 最后修改日期：2023-10-18 实验方法：X射线衍射（2.2 Å） 引用文献：《新型螺环衍生物作为强效可逆单酰甘油脂肪酶（MAGL）抑制剂的设计与合成：基于3-氧代-3,4-二氢-2H-苯并[b][1,4]恶嗪-6-基基团的生物电子等排转化》，J.Med.Chem., 64, 2021
创建时间：
2020-12-21
