Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with tunicamycin

Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with tunicamycin Descriptor: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Tunicamycin, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, ... Authors: Pike, A.C.W, Dong, Y.Y, Chu, A, Tessitore, A, Goubin, S, Dong, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Berridge, G, Wang, D, Kupinska, K, Belaya, K, Beeson, D, Burgess-Brown, N, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) Deposit date: 2017-06-01 Release date: 2018-02-28 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design. Cell, 175, 2018

人源UDP-N-乙酰葡糖胺-多萜醇磷酸N-乙酰葡糖胺磷酸转移酶（DPAGT1, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase）V264G突变体与衣霉素（tunicamycin）结合的晶体结构。配体描述：(2S)-3-{[{[(2S)-2,3-二羟基丙基]氧基}(羟基)磷酰]氧基}-2-[(6E)-十六碳-6-烯酰氧基]丙基 (8E)-十八碳-8-烯酸酯、衣霉素、UDP-N-乙酰葡糖胺-多萜醇磷酸N-乙酰葡糖胺磷酸转移酶（DPAGT1），…… 作者：Pike, A.C.W、Dong, Y.Y、Chu, A、Tessitore, A、Goubin, S、Dong, L、Mukhopadhyay, S、Mahajan, P、Chalk, R、Berridge, G、Wang, D、Kupinska, K、Belaya, K、Beeson, D、Burgess-Brown, N、Edwards, A.M、Arrowsmith, C.H、Bountra, C、Carpenter, E.P，结构基因组学联合体（Structural Genomics Consortium, SGC）。提交日期：2017-06-01；发布日期：2018-02-28；最后修改日期：2024-05-08。实验方法：X射线衍射（3.4 Å）。引用文献：《DPAGT1的结构阐释糖基化疾病机制并推动结核病抗生素设计》，《细胞（Cell）》，第175卷，2018年。