DYNAMIC CHANGES ININFLAMMATORY PROFILES OF THYROID DYSFUNCTION: A COMPARATIVE ANALYSIS OF HYPERTHYROIDISM AND HYPOTHYROIDISM

Introduction and Aim:The thyroid gland, an endocrine organ, produces vital hormones (T3 and T4) regulating metabolism. Thyroid-stimulating hormone (TSH) controls their release, impacting body tissues. C-reactive protein (CRP), an acute-phase protein, serves as a biomarker, crucial in diagnosing and managing various health conditions, particularly thyroid disorders. Elevated CRP levels often accompany thyroid dysfunction, highlighting the link between inflammation and thyroid disease pathogenesis, essential for diagnosis and management strategies.

Methods: The research was conducted at the College of Paramedical Sciences, Teerthanker Mahaveer University &Teerthanker Mahaveer Hospital & Research Center, Moradabad in India, using random sampling. Blood sample was collected in the vacutainer and serum was separated for the clinical examination of CRP by turbidimetric immunoassay method. Clinical examinations were estimated in the biochemistry lab at the College of Paramedical Sciences by using a Semiautoanalyser.

Results:The CRP levels in both hypothyroid and hyperthyroid groups were found higher as compared to euthyroid individuals, with mean CRP levels of 8.42 mg/dl, 5.67 mg/dl, and 5.05 mg/dl, respectively. A positive correlation between CRP and TSH is observed in hypothyroidism (r = 0.220). While hyperthyroidism exhibits slightly elevated CRP levels compared to healthy controls (5.67 mg/dl vs. 5.05 mg/dl), this difference lacks statistical significance (p>0.05). Notable variances in serum Hs-CRP levels are observed among individuals with hypothyroidism compared to euthyroidism (p<0.05), hyperthyroidism compared to euthyroidism (p>0.05), and hyperthyroidism compared to hypothyroidism (p<0.05), as determined by statistical analysis.

Conclusion:A notable elevation in CRP levels among individuals with hypothyroidism and hyperthyroidism compared to those with euthyroidism. Additionally, a positive correlation is observed between CRP and TSH levels, particularly in the hypothyroid group. The disparities in Hs-CRP levels among different thyroid conditions underscore the link between thyroid function and inflammatory status.