Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA

Data from ProteomeXchange, PXD ID: PXD001636. File: C1_1_TR1.mzml. Published as part of J Immunol. 2015 Sep 25 . From the Abstract: {{i}} Tissues accommodate defined numbers of dendritic cells (DCs) in highly specific niches where different intrinsic and environmental stimuli control DC life span and numbers. DC homeostasis in tissues is important, because experimental changes in DC numbers influence immunity and tolerance toward various immune catastrophes and inflammation. However, the precise molecular mechanisms regulating DC life span and homeostasis are unclear. We report that the GTPase RhoA controls homeostatic proliferation, cytokinesis, survival, and turnover of cDCs ... {{/i}}