Supplementary Tables S3-5 from Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis
Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked PHF6 gene. However, it is currently unknown how PHF6 regulates normal hematopoiesis and how
These bigWig files contain normalized ChIP-seq signal tracks generated from CD34+ PB-HSPCs and in vitro differentiated megakaryocytes and monocytes. The data represent genome-wide binding profiles of
Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Her
MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in MGA