Neurometabolic profile of the amygdala in smokers assessed with 1H-magnetic resonance spectroscopy - Data

1H-magnetic resonance spectroscopy (MRS) data and participant information for the article with the title: Neurometabolic profile of the amygdala in smokers assessed with 1H-magnetic resonance spectroscopy. The aims of the study were to compare glutamate and other metabolites in the amygdala (an area implied to play an important role in nicotine addiction) between smokers and controls, and between different smoking states. Furthermore, associations between amygdalar metabolite levels and smoking characteristics were explored. The data set comprises 28 male smokers and 21 non-smoking, matched controls. Controls were measured once (baseline) and smokers were measured in a baseline state (1-3 hours abstinence), during withdrawal (24 hours abstinence) and in a satiation state (directly after smoking). Voxel composition, spectral quality, and for the metabolites of interest, Cramér-Rao lower bounds and molar concentrations were measured using a novel non-water-suppressed 1H-MRS protocol. Good spectral quality, high anatomical specificity and reliable quantification of most metabolites of interest were achieved, providing first insights into the neurometabolic profile of the amygdala in smokers. Metabolite levels did not differ between groups, but smokers showed significantly lower glutamine levels at satiation than baseline. Details of the procedure and analysis are provided in the article (https://doi.org/10.1016/j.neuroimage.2024.120525).本数据集对应题为《采用氢质子磁共振波谱（1H-magnetic resonance spectroscopy, 1H-MRS）评估吸烟者杏仁核神经代谢特征》的研究，包含该研究的氢质子磁共振波谱数据及受试者信息。本研究旨在比较吸烟者与对照组，以及不同吸烟状态下杏仁核内谷氨酸及其他代谢物的水平——杏仁核被认为在尼古丁成瘾中发挥关键作用；此外还探索了杏仁核代谢物水平与吸烟特征之间的关联。本数据集包含28名男性吸烟者与21名特征匹配的非吸烟对照者。对照组仅在基线状态下接受一次扫描，吸烟者则分别在基线状态（戒断1-3小时）、戒断状态（戒断24小时）以及饱足状态（吸烟后即刻）接受扫描。本研究采用新型非水抑制氢质子磁共振波谱方案采集数据，记录了体素构成、波谱质量，以及目标代谢物的克拉美罗下界（Cramér-Rao lower bounds, CRLB）和摩尔浓度。最终获得了良好的波谱质量、较高的解剖特异性，并对多数目标代谢物实现了可靠定量，首次揭示了吸烟者杏仁核的神经代谢特征。研究结果显示，两组受试者的代谢物水平无显著差异，但吸烟者在饱足状态下的谷氨酰胺水平显著低于基线状态。本研究的实验流程与分析细节已发表于论文（https://doi.org/10.1016/j.neuroimage.2024.120525）。