Synthesis, Anti-Potato Virus Y Activities, and Interaction Mechanisms of Novel Quinoxaline Derivatives Bearing Dithioacetal Moiety

Quinoxaline
and its derivatives are important functional molecules
with a broad range of applications. Disclosed here is a design and
synthesis of a series of novel quinoxaline derivatives containing
dithioacetal moieties as well as their antiviral activities against
potato virus Y (PVY). The compound D30 was developed
on the basis of the three-dimensional quantitative structure–activity
relationship. The anti-PVY activity test showed that the half maximal
effective concentration of the anti-PVY protective activity of compound D30 is 197 μg/mL, which was better than the control
agents ningnanmycin (423 μg/mL) and xiangcaoliusuobingmi (281
μg/mL). Significantly, compound D30 can increase
defense enzyme activity and chlorophyll content, promote photosynthesis
by accelerating carbon fixation in tobacco, and further improve plant
disease resistance. All of these results suggest that compound D30 could be employed as a lead compound for novel PVY inhibitor
discovery.