Germline tumor formation in trd-1(RNAi) animals suggests a defect in the mitosis-meiosis switch.

Young adult animals (L4+1day) were stained with DAPI and the gonads scored for the presence of sperm and oocytes (essentially wild type gonads), germlines which contained only sperm (Sp), or only oocytes (Oo) or were tumorous (Tum), a phenotype in which no differentiated nuclei are observed in the germline and all nuclei remain in mitosis. trd-1 RNAi synergistically enhances the Tum phenotype of gld-3(q741) mutants.Germline tumor formation in trd-1(RNAi) animals suggests a defect in the mitosis-meiosis switch.