HDAC inhibition enhances the in vivo efficacy of MEK inhibitor therapy in uveal melanoma
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https://www.ncbi.nlm.nih.gov/sra/SRP187753
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Purpose: The clinical use of MEK inhibitors in uveal melanoma is limited by the rapid acquisition of resistance. The current study has used unbiased multi-omics and drug screens to identify the pan-HDAC inhibitor panobinostat as an effective strategy to limit MEK inhibitor resistance. Overall design: Examination of 92.1 uveal melanoma cell lines treates with two different single agent inhibitors and their combination compared to the vehicle control.
创建时间：
2022-10-20
