Convenient Direct Synthesis of Bisformylated Calix[4]arenes via <i>I</i><i>pso</i> Substitution
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A facile synthesis of bisformylated calix[4]arenes via ipso substitution of p-tert-butylcalix[4]arenes through treatment with hexamethylenetetramine/trifluoroacetic acid is described. Under identical conditions, p-tert-butylcalix[4]arene tetramethyl ether 4 gives proximally substituted bisformylated derivative 4a in a pinched cone conformation.
创建时间:
2006-05-25



