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Adaptive upregulation of Clumping Factor A (ClfA) by S. aureus in the obese, type 2 diabetic host mediates increased virulence. Staphylococcus aureus

NIAID Data Ecosystem2026-03-10 收录

金黄色葡萄球菌毒力

代谢性疾病与骨科感染

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA378646 数据链接链接失效反馈

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资源简介：

Determination of S. aureus adaptation to obese/T2D host in chronic orthopaedic infection Overall design: Mice were infected with S. aureus for 14d by transtibial orthopaedic implant at 200k CFU/pin. RNA from mouse and S. aureus were isolated from infected tibiaie

应用场景：

创建时间：

2017-03-09

细菌耐药性机制

金黄色葡萄球菌毒力

In summary, this study shows advantages of the CIP-R in the survival, drug resistance and virulence in iron restricted condition. DIA-based proteomics study combined with biochemical validation showed

NIAID Data Ecosystem70

This study describes the target receptor and mechanism of action of Staphylococcal superantigen like 13 (SSL13), a secret protein reside on S.aureus immune evasion cluster 2(IEC-2) that previously supposed to modulate immune evasion. In sharp contrast to the characterized SSLs located on the staphylococcal pathogenicity island 2 (SPI-2) , that inhibit immune functions, We demonstrate SSL13 is a chemoattractant and a neutrophil activator that acts via the FPR2. Therefore, SSL13 is a unique SSL member not belonging to the immune evasion class, but is a pathogen alarming molecule sensed by the FPR2. Our study provides a new conception of SSLs, that not only inhibit host immune processes but also recruit human neutrophils to the site of infection, where S. aureus can be disarmed by secreted immune evasion proteins and used as vesicles to other parts of the host. This allow us to better understand of S. aureus pathological processes.

金黄色葡萄球菌毒力

中性粒细胞免疫

Staphylococcal Superantigen-Like (SSL) proteins, one of major virulence factor families produced by Staphylococcus aureus, were previously demonstrated to be immune evasion molecules that interfere wi

NIAID Data Ecosystem30

Transcriptomic analysis of rsp deficient Staphylococcus aureus

金黄色葡萄球菌毒力

转录组差异

We provide the transcriptomic profile of rsp deficient Staphylococcus aureus in order to elucidate the impact upon virulence. S. aureus RNA was extracted to compare global gene expression of two sampl

NIAID Data Ecosystem10

Comparison of transcriptomic contents of a wild type Staphylococcus strain (HG001) and the spdC deleted derivative by RNAseq analysis.. Identification of SpdC regulated genes

金黄色葡萄球菌毒力

细菌双组分系统

We have characterized links between the SpdC protein and the WalKR two-component system. We have generated an spdC-deleted strain. This strain behaves like the WT parental strain, at least concerning

NIAID Data Ecosystem70

Data of the paper.pdf

细菌耐药性机制

金黄色葡萄球菌毒力

Glutamate metabolism plays a pivotal role in linking the tricarboxylic acid cycle, arginine biosynthesis, and purine metabolism and these pathways have been shown to be involved in persister formation

Figshare2024-06-13 更新10

Adaptive upregulation of Clumping Factor A (ClfA) by S. aureus in the obese, type 2 diabetic host mediates increased virulence. Staphylococcus aureus

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