RawData_NTA_EVs

Nanoparticle Tracking Analysis (NTA) data are obtained from EVs isolated from 120 human plasma samples, n=30 Alzheimer’s disease (AD), n=30 Lewy body dementia (LBD), n=30 sporadic frontotemporal dementia (FTD) patients and n=30 elderly subjects with normal cognitive function, as control group (CTRL). Moreover, a negative control was included in the analysis (ctrl_neg). Samples were analyzed with Nano-Sight NS300 Instrument (Malvern, Worchestershire, UK). For each sample, 5 video of 60 seconds duration were recorded and data were processed using NanoSight NTA Software 3.2 (Malvern, Worchestershire, UK). Correspondence_RawData table shows sample code, category as diagnostic group, age, sex and the corresponding raw file name. Raw data of each sample analyzed consists of .csv file generated by Nano-Sight NS300 Instrument. File contains information about EVs concentration (particles/ml, particles/frame), size (mean, mode, SD) and size distribution (D10, D50 and D90).纳米颗粒追踪分析（Nanoparticle Tracking Analysis, NTA）数据源自120份人类血浆样本中分离得到的细胞外囊泡（Extracellular Vesicles, EVs）。本数据集共包含4组样本：阿尔茨海默病（Alzheimer’s disease, AD）患者、路易体痴呆（Lewy body dementia, LBD）患者、散发性额颞叶痴呆（sporadic frontotemporal dementia, FTD）患者各30例，另有30例认知功能正常的老年受试者作为对照组（CTRL）；此外本次分析还纳入了阴性对照（ctrl_neg）。所有样本均使用英国伍斯特郡马尔文仪器公司的Nano-Sight NS300仪器完成检测。针对每份样本，录制5段时长为60秒的视频，并通过英国伍斯特郡马尔文仪器公司的NanoSight NTA软件3.2版处理所得数据。Correspondence_RawData表包含样本编码、诊断组别、年龄、性别以及对应的原始文件名。每份待测样本的原始数据为Nano-Sight NS300仪器生成的.csv格式文件，文件中包含细胞外囊泡的浓度信息（颗粒数/毫升、颗粒数/帧）、粒径信息（均值、众数、标准差）以及粒径分布数据（D10、D50与D90）。