Supporting data for "Effects of Bone Marrow-Derived Extracellular Vesicles on Fracture Healing"

Fracture healing is an orchestrated process involving intricate interactions between periosteal osteoprogenitor cells and bone marrow (BM) immune cells. However, the specific mechanisms through which cells in these distinct niches communicate remain unclear. In our study, we show that long bone fracture leads to the production of a considerable number of pro-regenerative extracellular vesicles (EVs) derived primarily from immune cells in BM. This dataset, compiled from multiple experiments, unveils a previously unknown mechanism for EVs-based direct communication between BM immune cells and periosteal bone-forming cells, which is crucial for fracture healing.

骨折愈合是一个由骨外膜成骨祖细胞与骨髓免疫细胞之间复杂相互作用所调控的过程。然而，这些不同微环境中细胞间的具体通讯机制尚不明确。在我们的研究中，我们揭示了长骨骨折会导致骨髓免疫细胞产生大量促进再生的细胞外囊泡（EVs）。本数据集由多个实验汇编而成，揭示了骨髓免疫细胞与骨外膜成骨细胞之间基于EVs的直接通讯的先前未知机制，这对于骨折愈合至关重要。