Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor
收藏Protein Data Bank Japan2024-02-28 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/4e4x
下载链接
链接失效反馈官方服务：
资源简介：
Crystal Structure of B-Raf Kinase Domain in Complex with a Dihydropyrido[2,3-d]pyrimidinone-based Inhibitor Descriptor: N-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide, Serine/threonine-protein kinase B-raf Authors: Voegtli, W.C, Sturgis, H.L. Deposit date: 2012-03-13 Release date: 2012-05-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.6 Å) Cite: The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 22, 2012
与二氢吡啶并[2,3-d]嘧啶酮类抑制剂结合的B-Raf激酶结构域晶体结构
描述符：N-(2,4-二氟-3-{2-[(3-羟丙基)氨基]-8-甲基-7-氧代-7,8-二氢吡啶并[2,3-d]嘧啶-6-基}苯基)丙烷-1-磺酰胺，丝氨酸/苏氨酸蛋白激酶B-Raf
作者：Voegtli, W.C.、Sturgis, H.L.
提交日期：2012-03-13
发布日期：2012-05-09
最后修改日期：2024-02-28
实验方法：X射线衍射（分辨率3.6 Å）
引用文献：《强效选择性B-Raf(V600E)激酶吡啶并嘧啶-7-酮类抑制剂的发现》，Bioorg.Med.Chem.Lett., 22, 2012
创建时间：
2012-03-13
