β-catenin stabilization in lens fiber cells results in cataract.
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(A) Schematic diagram of delβ-CAT transgenic construct. (B) delβ-CAT transgenic protein is detected in adult mutant lenses (Tg) with anti-Ha-tag antibody. (C) N-terminally deleted β-catenin is detected in transgenic lenses (Tg) with anti-β-catenin antibody. Note that the delβ-cat protein is expressed in higher amount than endogenous β-catenin. (D) qRT-PCR demonstrates upregulated mRNA expression of Axin2 in newborn delβ-CAT lenses (*p
创建时间：
2016-02-23
