TPE genes containing major sequence changes encoding proteins with predicted cell function.

T. p. ssp. pertenue (TPE) genes encoding proteins with predicted cell function containing six or more amino acid changes and/or major sequence changes between all studied T. p. ssp. pertenue and all T. p. ssp. pallidum strains are shown.aD, deletion; fr. mut., frameshift mutation; I, insertion; MSC (major sequence changes) are defined in Table 1; rev. fr. mut., reverted frameshift mutation; S, substitution.bGene expression rate in Nichols strain grown in rabbits. The gene expression rates were taken from [58].cThe gene was shown to contain frameshift mutations or MSC in the genome of Treponema paraluiscuniculi Cuniculi A [33].dDetected recombination within the gene or previously identified recombination [56].eThe corresponding protein was identified as an antigen [54].fThe corresponding protein was identified as a lipoprotein [55].gThe selection test was calculated using the Kumar model [47] using MEGA4 [48] software.