Paired marker analysis for <i>HLA-DRB1*15:01</i> and rs4959039 haplotypes in the merged dataset.

Two locus haplotypes were constructed and the odds ratio for association with MS susceptibility for each haplotype was tested in a logistic regression model treating each haplotype as a categorical variable. The odds ratio for the HLA-DRB1*15:01 allele in the merged dataset was 3.50 (p<1.46×10−100). All results are adjusted for stratification effects caused by sex, location (US versus UK) and dataset (discovery versus replication). DRB1*X refers to subjects who do not carry the HLA-DRB1*15:01 allele.