Skin Microbiome Dynamics Following B. subtilis formulation Challenge

Modulating the microbiome is a leading-edge strategy for the restoration and maintenance of a healthy, balanced environment. The use of health-promoting bacteria is emerging as an alternative for skin microbiome intervention, showing promising results. Bacillus subtilis, with its non-pathogenic and antibacterial properties, has great potential as a microbiome-manipulating agent. Here, we investigate the experimental manipulation of the skin microbiome using B. subtilis incorporated into a supportive Pluronic F-127 hydrogel formulation. Indeed, the formulation is of prime importance for dermal bacterial delivery, determining the ability of live bacteria to become established at the desired action site.