PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04A07 from the F2X-Universal Library

PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04A07 from the F2X-Universal Library Descriptor: 4-(thiophene-2-sulfonyl)morpholine, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 Authors: Barthel, T, Wollenhaupt, J, Lima, G.M.A, Wahl, M.C, Weiss, M.S. Deposit date: 2022-08-26 Release date: 2022-11-02 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65, 2022

PanDDA分析组提交数据集——Aar2/核糖核酸酶H（RNaseH）与F2X通用文库的片段P04A07形成的复合物。结构描述符：4-(噻吩-2-磺酰基)吗啉，靶标蛋白为A1顺反子剪接因子AAR2与前mRNA剪接因子8。作者：Barthel, T.、Wollenhaupt, J.、Lima, G.M.A.、Wahl, M.C.、Weiss, M.S.。提交日期：2022-08-26，发布日期：2022-11-02，最后修改日期：2024-05-22。实验方法：X射线衍射法（分辨率1.35埃）。引用文献：《大规模晶体学片段筛选加速化合物优化并鉴定潜在蛋白质-蛋白质相互作用位点》，J.Med.Chem.，第65卷，2022年。