Immediate cause of death for patients with IA.

1 More than >1 cause of death was considered in 38 patients.2 Differences between IA-related and IA-related mortality.3 Cytomegalovirus, 7 patients; Pseudomonas aeruginosa, 5 patients; Pneumocystis jirovecii, 3 patients; Influenza A(H1N1)pdm09, 3 patients; Streptococcus pneumoniae, 2 patients; nocardiosis, 2 patients; Rhodococcus equi, 1 patient; respiratory syncytial virus, 1 patient; aspiration pneumonia, 1 patient. Three respiratory co-pathogens were found in 5 patients.4 Severe chronic obstructive pulmonary disease, 8 patients; GVHD, 3 patients; and in 1 patient each: cerebrovascular disease, lung cancer, pulmonary fibrosis, and acute pulmonary thromboembolism.5 Acute myeloid leukemia relapse, 6 patients; graft failure in organ solid recipients, 4 patients (two lung, one kidney, one liver); GVHD, 4 patients with allo-hematopoietic stem cell transplantation; cavum massive hemorrhage secondary to solid cancer, 1 patient; advanced lung cancer, 1 patient; intestinal obstruction in patient with metastatic cancer, 1 patient; severe aplasia after chemotherapy in one patient with chronic lymphocytic leukemia.6 Gram-negative bacilli, 6 patients; Enterococcus spp., 4 patients; Listeria monocytogenes, 1 patient; Streptococcus pneumoniae, 1 patient; Candida albicans, 1 patient; polymicrobial bacteremia with Enterococcus faecim and Achromobacter dentrificans, 1 patient.7 Necrotizing pneumonia caused by Aspergillus in patients with severe pancytopenia due to hematologic disease, 5 patients (in one case co-infection with Pseudomonas aeruginosa was found); necrotizing pneumonia caused by Aspergillus in patients with pancytopenia and/or coagulopathy due to liver disease, 3 patients; necrotizing pneumonia caused by Aspergillus, 1 case; necrotizing pneumonia caused by Aspergillus and Pseudomonas aeruginosa, 1 case.8 Brain herniation caused by focal lesion +/- cerebral hemorrhage caused by Aspergillus in central nervous system, 5 patients; cerebral ischemic event, 2 patients; primary brain hemorrhage, 1 patient.9 Disseminated invasive aspergillosis with multiorganic failure, 3 cases; multiorganic failure caused by respiratory failure due to Aspergillus and liver failure due to severe underlying liver disease, 3 patients; multiorganic failure caused by respiratory failure due to Aspergillus and heart failure after cardiac transplantation, 1 patient.10Clostridium difficile infection, 4 patients (co-infection with CMV was found in 1 case); sudden cardiopulmonary arrest in patients with multifactorial encephalopathy, 2 patients; sudden cardiac arrest, 2 patients; acute myocardial ischemia, 1 patient; neutropenic colitis, 1 patient, intestinal ischemia and secondary peritonitis, 1 case; post-surgical esophageal perforation and secondary mediastinitis, 1 case; severe cachexia (adult/32 kg), 1 case; diabetic ketoacidosis, 1 case.Immediate cause of death for patients with IA.