RNAseq in Pten enhancer wild-type or deleted mouse T-ALLs
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https://www.ncbi.nlm.nih.gov/sra/SRP262417
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资源简介：
C57BL6 mice harboring Pten enhancer (PE) conditional knockout NOTCH1-induced leukemias were treated with vehicle (control) or tamoxifen to induce isogenic deletion of PE. Here we report the gene expression profile of leukemic blasts obtained from the spleen from control- or tamoxifen-treated leukemic mice. GSEA analysis show a significant enrichment of Pten signature genes, consistent with a role of PE in regulating Pten expression. Overall design: RNAseq analysis of leukemic spleens in two genotypes and four or five samples per genotype.
创建时间：
2021-03-19
