TRS-BIOME

This dataset contains metagenomics data from stool samples collected from 97 adult (18-65) participants from Brisbane, Queensland, Australia collected between October 2020-November 2021. These participants were recruited across four groups: non-psychiatric controls, people with schizophrenia responding to first-line atypical antipsychotics, people with treatment-resistant schizophrenia responding to clozapine, and people with treatment-resistant schizophrenia not responding to clozapine. The data was used in Vasileva et al. 2024 (publshed in JAMA Psychiatry). This dataset contains the raw sequencing files (FASTQ), taxonomic and functional counts provided by Microba Inc, and metadata.本数据集包含宏基因组学（metagenomics）数据，样本采集于2020年10月至2021年11月间，来源于澳大利亚昆士兰州布里斯班市的97名成年（18-65岁）受试者的粪便样本。上述受试者被分为四组：非精神疾病对照组、接受一线非典型抗精神病药物治疗的精神分裂症患者、对氯氮平应答的难治性精神分裂症患者，以及对氯氮平无应答的难治性精神分裂症患者。该数据集相关数据曾被用于Vasileva等人2024年发表于《JAMA Psychiatry》（《美国医学会精神病学杂志》）的研究。本数据集包含由Microba Inc提供的原始测序文件（FASTQ）、分类学与功能计数数据，以及样本元数据。