The data of differentially regulated exons from mouse testes - wild-type and Dazap1 mutant

The binding of Deleted in Azoospermia Associated Protein 1 (DAZAP1) to splicing mutations in the BRCA1 and NF1 genes that caused exon exclusion suggest a role for DAZAP1 in RNA splicing. To elucidate the biological functions of DAZAP1 and to search for its natural RNA substrates, we compared the exon usages of wild-type and Dazap1 mutant testes by exon microarrays. We used wild-type and Dazap1 mutant mouse testes. Each genotype has three replicates. 6 total samples were analyzed.无精子症缺失相关蛋白1（Deleted in Azoospermia Associated Protein 1，DAZAP1）与BRCA1及NF1基因中引发外显子排除的剪接突变相结合，提示DAZAP1在RNA剪接过程中发挥作用。为阐明DAZAP1的生物学功能并搜寻其天然RNA底物，我们通过外显子微阵列（exon microarrays）比较了野生型与Dazap1突变型小鼠睾丸的外显子使用情况。本研究采用野生型及Dazap1突变型小鼠睾丸样本，每种基因型设置3个生物学重复，总计分析6个样本。