How proteins fold from their linear sequence into their functional structures is still not understood and the misfolding of proteins is linked to a variety of diseases - such as...
TDP-43 proteinopathies is a disease hallmark that characterizes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The N-terminal domain of TDP-43 (NTD) is important to
Protein refolding is an important process to recover active recombinant proteins from inclusion bodies. Refolding by simple dilution, dialysis and on-column refolding methods are the most common techn
Using the PathMolD-AB software, four datasets of protein folding trajectories were produced as case studies. Four proteins were simulated, one artificially created and three real-world proteins with a
Using the PathMolD-AB software, four datasets of protein folding trajectories were produced as case studies. Four proteins were simulated, one artificially created and three real-world proteins with a
