Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds
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https://figshare.com/articles/dataset/Synthesis_and_Anti_influenza_A_Virus_Activity_of_2_2_Dialkylamantadines_and_Related_Compounds/2460532
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资源简介：
The synthesis of several 2,2-dialkyladamantyl-1-amines
through
the combination of a Ritter reaction with a Wagner–Meerwein
rearrangement from noradamantane alcohols is reported. Several of
the novel amines displayed low micromolar activities against several
H1N1 influenza virus strains, including the amantadine-resistant A/PuertoRico/8/34
strain. Most of the compounds did not show cytotoxicity for MDCK cells.
创建时间：
2012-12-13
