Transcriptomic analysis of human foetal hearts with or without Down Syndrome. Transcriptomic analysis of human foetal hearts with or without Down Syndrome

We performed bulk RNAseq on whole hearts from foetuses with Down syndrome and age-matched, sex-matched euploid controls. Analysis showed the expected increased expression of the genes on Hsa21 that are present in 3 copies. Gene set enrichment analysis identified pathways that are altered in DS hearts. Overall design: RNAseq on 5 human embryonic hearts with Down syndrome and on 5 euploid age- and sex-matched control hearts.