Pyruvate is effective in restoring cataracts formed by galactose-induced cataract models.. Pyruvate is effective in restoring cataracts formed by galactose-induced cataract models.

The addition of Pyruvate to the lens induced by galactose eliminated the white clouding formed and showed a therapeutic effect. Genes regulated by pyruvate addition were identified by microarray analysis. A total of seven samples were used in this analysis: two samples without galactose (control), three samples with galactose (galactose) and two samples with Pyruvate (Pyruvate). Overall design: Genes that increased in galactose-treated lenses and reverted with Pyruvate were extracted.