Role of SAA1-2 of systemic inflammation in the 4T1 murine breast cancer model. Mus musculus

Cancers induce the production of acute phase proteins such as serum amyloid alpha (SAA) in the liver and cause systemic inflammation. Despite the well-known coincidence of acute phase response and systemic inflammation, the direct roles of SAA proteins in systemic inflammation in the cancer context remains incompletely characterized, particularly in vivo. In this study, we aim to investigate the in vivo significance of SAA proteins in systemic inflammation in the 4T1 murine breast cancer model.