Spearman rank correlation coefficients for comparisons between participant characteristics and main outcomes as well as blood biomarker levels.

Pairwise case deletion was used for missing observations. Abbreviations: ACE = angiotensin-converting enzyme. BDI-II = Beck Depression Inventory II. CABG = coronary artery bypass grafting. COPD = chronic obstructive pulmonary disease. hs-CRP = high-sensitivity C-reactive protein. IL-6 = interleukin-6. NYHA = New York Heart Association. S-100B = S-100 calcium-binding protein B.*P†Acute Δ refers to the primary outcome, acute change in depressive symptom severity, defined as the intra-subject difference between BDI-II scores at baseline and discharge.‡Delayed Δ refers to the secondary outcome, delayed change in depressive symptom severity, defined as the intra-subject difference between BDI-II scores at baseline and six-month follow-up.§Total Δ refers to the intra-subject difference in blood biomarker levels between baseline and 2 days postoperative.||Within 7 days before the index procedure.††Missing data (from left to right): n = 3; n = 1; n = 3; n = 2; n = 2; n = 3; n = 2; n = 3; n = 2.‡‡Missing data (from left to right): n = 0; n = 1; n = 3; n = 2; n = 2; n = 3; n = 2; n = 3; n = 3.§§Missing data (from left to right): n = 0; n = 1; n = 0; n = 0; n = 0; n = 0; n = 0; n = 0; n = 0.Spearman rank correlation coefficients for comparisons between participant characteristics and main outcomes as well as blood biomarker levels.