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A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia [10X Genomics]

NIAID Data Ecosystem2026-03-14 收录

干细胞自我更新调控

白血病转录网络

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE175516 数据链接链接失效反馈

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资源简介：

We uncover a key transcriptional network involving hundreds of genes that is required for HSC self-renewal. MECOM impact on the hematopoietic stem cells

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创建时间：

2022-11-25

干细胞自我更新调控

胚胎干细胞研究

Previously, we identified the transcription factor Zfx as a key regulator of self-renewal in murine ESCs. Here we extend those findings to human ESCs. Zfx knockdown in hESCs hindered clonal growth and

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This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

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Macrophage-secreted CSF1 transmits a calorie restriction self-renewing signal to mammary epithelial stem cells

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细胞能量代谢

Calorie restriction (CR) enhances stem cell self-renewal in various tissues, including the mammary gland. The hypothesis propelling this study states that similarly to their intestinal counterparts, m

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The B-MYB Transcriptional Network Guides Cell Cycle Progression and Fate Decisions to Sustain Self-Renewal and the Identity of Pluripotent Stem Cells

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Embryonic stem cells (ESCs) are pluripotent and have unlimited self-renewal capacity. Although pluripotency and differentiation have been examined extensively, the mechanisms responsible for self-rene

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Tip5/Baz2a Regulates Chromatin Architecture and Gene Expression to Maintain Self-renewal and Pluripotency of Embryonic Stem Cells [microarray]

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染色质架构与基因表达调控

It is unclear how gene networks that regulate self-renewal and pluripotency of embryonic stem (ES) cells are established. We searched for factors that contribute to forming functional chromatin archit

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A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia [10X Genomics]

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