Effect of an oxaliplatin injection on spinal NR2B protein expression and phosphorylation at day 3 in rats fed with a normal diet.

Variations (%) in total NR2B, p-Tyr1472, p-Tyr1336 and p-Ser1303 NR2B expression were measured in the spinal cord dorsal horn of control rats (normal diet - CT, white bars) and oxaliplatin-treated rats (6 mg/kg, i.p., normal diet - OXA, black bars) 3 days after oxaliplatin administration. Ratios on beta-actin are expressed as means ± SEM. Representative western blots are shown for NR2B/phospho-NR2B (upper panel) and the corresponding beta-actin signals (lower panel). A non-parametric Mann-Whitney-Wilcoxon test was used to assess statistical differences between groups.