YAP1 binds TP73

YAP1, phosphorylated on tyrosine residue Y407 (Y357 in the splicing isoform 3, known as YAP1-1beta) by the protein tyrosine kinase ABL1, activated in response to DNA damage, forms a complex with TP73. ABL1-phosphorylated YAP1 can no longer bind RUNX1 (Levy, Adamovich et al. 2008; Levy, Reuven and Shaul 2008). Binding of phosphorylated YAP1 to TP73 may target TP73 to promoters of pro-apoptotic target genes instead of cell cycle arrest genes (Levy, Adamovich et al. 2008).

YAP1（在剪接异构体3中称为YAP1-1beta，其中酪氨酸残基Y407被酪氨酸激酶ABL1磷酸化，Y357被磷酸化），在DNA损伤的刺激下被激活，与TP73形成复合物。ABL1磷酸化的YAP1无法再与RUNX1结合（Levy, Adamovich等，2008；Levy, Reuven和Shaul，2008）。磷酸化的YAP1与TP73的结合可能将TP73靶向至促凋亡靶基因的启动子，而非细胞周期停滞基因（Levy, Adamovich等，2008）。