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Associated data for The impact of storage conditions on the stability of clinical and experimental pharmaceuticals

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Research Data Australia2024-08-17 收录
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https://researchdata.edu.au/associated-the-impact-experimental-pharmaceuticals/2046065
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This dataset contains 3 sets of data from the research project "The Impact of Storage Conditions on the Stability of Clinical and Experimental Pharmaceuticals":1. Raw concentration and pH results for remifentanil and propofol mixed with a number of diluents, both in isolation and when combined. Data was obtained using high performance liquid chromatography (HPLC) and a pH meter.2. Raw concentration, pH, protein monomer, single-chain protein and bioactivity data for tenecteplase subjected to heat treatment, as well as raw temperature data for a preliminary study determining maximum temperature reached within ambulances (where tenecteplase is often stored). Data was obtained using a thermometer, pH meter, UV spectrometer, size exclusion chromatography (SEC) and a coagulation analyser.3. Raw concentration and pH data for EBC-46 when subjected to temperature, light, air and pH treatments, as well as its metabolism in an ex vivo model. Data was obtained using high performance liquid chromatography (HPLC), liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), and a pH meter.

本数据集包含来自研究项目《储存条件对临床与实验用药物稳定性的影响》的3组数据: 1. 瑞芬太尼(remifentanil)与丙泊酚(propofol)分别与多种稀释剂单独混合、以及二者联合混合时的原始浓度与pH值结果。该数据通过高效液相色谱法(High Performance Liquid Chromatography, HPLC)与pH计测得。 2. 接受热处理的替奈普酶(tenecteplase)的原始浓度、pH值、蛋白质单体、单链蛋白与生物活性数据,以及一项初步研究的原始温度数据——该研究旨在测定替奈普酶常用储存环境——救护车内部所能达到的最高温度。该批数据通过温度计、pH计、紫外分光光度计、尺寸排阻色谱法(Size Exclusion Chromatography, SEC)与凝血分析仪测得。 3. EBC-46在经受温度、光照、空气与pH值处理后的原始浓度与pH值数据,以及其在离体模型中的代谢情况数据。该数据通过高效液相色谱法(High Performance Liquid Chromatography, HPLC)、液相色谱-串联质谱联用法(Liquid Chromatography coupled with Tandem Mass Spectrometry, LC-MS/MS)与pH计测得。
提供机构:
Central Queensland University
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