Gene expression data of testis of PND 30 Sprague-Dawley rats (SD:Hsd) dosed prenatally and lactationally with HMB

2-hydroxy-4-methoxybenzophenone (HMB) has been reported to have weak estrogenic activity by in vivo and in vitro studies, making it a chemical with potential reproductive concern. To explore if perinatal HMB exposure altered the gene expression profiling in the rat testis, we analyzed whole genome and mitochondria-related gene expression profiling on the testis ontained from Sprague-Dawley rat offspring exposed prenatally and lactationally to varying dose of HMB. Time-mated Sprague-Dawley female rats (11-13 weeks old) were provided ad libitum low-phytoestrogen chow containing 0 (control), 3000, or 30000 ppm HMB from GD 6-PND 21. Testis from PND 30 male Sprague-Dawley rats exposed prenatally and lactationally to HMB were collected (n=5 per group). RNA were extracted and used for whole genome expression array (Agilent Technologies; 8 x 60K format).