Highly Regio- and Enantioselective Formal [3 + 2]-Annulation of Indoles with Electrophilic Enol Carbene Intermediates
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https://figshare.com/articles/dataset/Highly_Regio-_and_Enantioselective_Formal_3_2_-Annulation_of_Indoles_with_Electrophilic_Enol_Carbene_Intermediates/3803916
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资源简介：
Chiral cyclopentane-fused
indolines are synthesized with high regio-
and enantiocontrol by formal [3 + 2]-annulation reactions of indoles
and electrophilic enol carbenes. High enantioselectivity and exclusive
regiocontrol occurred with enoldiazoacetamides using a less sterically
encumbered prolinate-ligated dirhodium(II) catalyst in reactions with N-substituted indoles without substituents at the 2- or
3-positions via a selective vinylogous addition process. In this transformation,
donor–acceptor cyclopropenes generated from enoldiazoacetamides
serve as the carbene precursors to form metal carbene intermediates.
创建时间：
2016-09-12
