Detailed overview of serodiagnostic tests and antigens for VL in the diagnostic development pipeline.

For tests evaluated in multiple studies the lowest and highest values are taken for the sensitivity and specificity range. For the meta-analysis reports, the confidence intervals are considered as the range. Highlighted in grey are the tests that meet the cut off of >94% sensitivity and >97% specificity for an ideal test defined by Boelaert et al, 2007 [25]. ß -ME: beta-mercaptoethanol, DAT: Direct Agglutination Test, ELISA: enzyme-linked immunosorbent assay, FACS: fluorescence-activated cell sorting, ICT: immunochromatographic test, IFAT: indirect fluorescent antibody technique, kDa: kilodalton, r: recombinant, SDS-PAGE: sodium dodecyl sulfate polyacrylamide gel electrophoresis, SLA: soluble leishmanial antigen, WB: Western blot.