Myeloid FtH deficiency accelerates kidney disease by inducing Snca and ferroptosis [Baseline WT-KO]

To investigate impact of myeloid ferritin heavy chain (FtH) deletion in kidney iron metabolism under baseline conditions, we performed bulk RNA sequencing on kidney tissues from FtHfl/fl (wild-type) and FtH?/? (myeloid-specific FtH-deficient) mice. Overall design: Total RNA was isolated from kidney using Trizol from wild-type (FtHfl/fl) n=4 and myeloid specific FtH deficient (FtH?/?) n=4 mice under quiescent conditions. We then perfomed gene expression profilling analysis using RNA -Seq