Gene expression in primary acute lymphoblastic leukemia (ALL) associated with methotrexate treatment response

Genome-wide assessment of gene expression in primary acute lymphoblastic leukemia cells was performed to identify genomic determinants of MTX’s antileukemic effects. Reduction of circulating leukemia cells after in vivo methotrexate treatment served as a measure MTX's antileukemic effects. Keywords: gene expression associated with drug response Gene expression in diagnostic primary acute lymphoblastic leukemia cells from bone marrow of 161 pediatric patients