Transcription profiling of blood in mice exposed Unpredicatble Chronic Mild Stress and treated with fluoxetine. Mus musculus

Groups of 8 adult BALB/c male mice were either untreated or exposed for 9 weeks to unpredicatble chronic mild stress (UCMS), or exposed for 7 weeks to UCMS and treated for the last 5 weeks with fluoxetine (Flx) diluted in drinking water, or untreated for 2 weeks and received Flx for 5 weeks. Total RNAs from whole blood (WB) were profiled after hybridization with Agilent SurePrint G3 Mouse GE 8x60K Microarray v1 to identify transcriptional biomarkers of major depression. Overall design: Total RNAs were extracted from 32 samples including: (8 control, 8 UCMS, 8 UCMS+Flx, 8 Flx) for whole blood.