NHLBI TOPMed: Genetic Epidemiology Network of Salt Sensitivity (GenSalt)

The GenSalt study aims to identify genes which interact with dietary sodium and potassium intake to influence blood pressure in Han Chinese participants from rural north China. Whole genome sequencing will be conducted among 1,860 participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) Study. We will work in collaboration with participating TOPMed studies to identify novel common, low-frequency and rare variants associated with an array of cardiometabolic phenotypes. In addition, we will explore the relation of low-frequency and rare variants with salt-sensitivity among GenSalt study participants.]]>
TOPMed Whole Genome Sequencing Methods: Freeze 8TOPMed Whole Genome Sequencing Methods: Freeze 9Inclusion criteria for proband Men or women aged 18-60 years Systolic BP 130-160mm Hg and/or diastolic BP 85-100mm Hg Both parents (two-generation nuclear family) or at least one parent (three or more generation family) are available and willing to participate in the study At least one sibling meets eligibility criteria for participation Inclusion criteria for siblings/spouses/offspring Men or women aged 18-60 years for siblings or aged =16 years for offspring Living in the same village with proband Exclusion criteria for probands/siblings/spouses/offspring Current stage-2 hypertension (systolic BP =160mm Hg and/or diastolic BP =100mm Hg) Current or recent (less than 1 month before screening visit) use of antihypertensive medications or medications that affect BP Secondary hypertension History of clinical cardiovascular disease, including myocardial infarction, congestive heart failure, stroke and peripheral arterial disease Chronic kidney failure or urinary albumin concentration =20 mg/dl Current diabetes (fasting serum glucose =126 mg/dl) or use of insulin or oral hypoglycaemic agents Peptic ulcer disease requiring treatment during the previous 2 years Liver disease requiring treatment during the previous 2 years Currently pregnant women Heavy alcohol drinkers (more than 14 drinks per week) Currently adhering to a low-sodium diet Inability or unwillingness to participate or sign informed consent form ]]>